You have landed on this page because the game detected an error while attempting to start.
The issue occurs because the game failed to load a mandatory shader file.
This might happen because your game installation has a broken file. Please Verify Game Data Integrity, or if using a different platform, try uninstalling and reinstalling the game. If that solves it for you, please let us know!
One way that this can happen is if mods are installed, which either reference a non-existent shader file or remove a mandatory one.
Requesting further support
If you have ended up on this page and ruled out all of the potential causes above, please send a mail to email@example.com (Subject: Exitcode 1046) with a screenshot of the popup error and your dxdiag as well as the vulkaninfo attached. This Wiki entry explains how to create this information.